造血干细胞移植后认知功能的恢复

2007-11-05 16:45:58   作者：   文字大小：【大】【中】【小】

Last Updated: 2007-10-29 16:07:44 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Cancer patients appear to show negative changes in cognitive functioning associated with hematopoietic stem cell transplantation (HSCT), but values return to a normative level within a year.
纽约（路透社 健康）——接受造血干细胞移植的癌症病人似乎在认知功能方面表现出一些衰退的迹象。但是在一年内，这些功能会恢复到正常水平。

Dr. Margaret Booth-Jones of the H. Lee Moffitt Cancer Center and Research Institute in Tampa, Florida, and colleagues note that there have been reports of cognitive deficits in patients undergoing HSCT.
H. Lee Moffitt癌症中心和研究所的Margaret Booth-Jones博士和他的同事注意到已经有了关于病人接受造血干细胞移植后出现认知缺陷的报道。

To investigate, the researchers initially studied 286 patients who were randomized to be tested pre-transplant and 6 and 12 months, and another 124 were tested at 6 and 12 months. Eighty-three patients who were tested at 12 months only were not included in the analysis. The most frequent cancer diagnosis was multiple myeloma (in 63%).
为深入研究这个现象，研究人员最初随机选择了286位病人，对他们在移植前，移植后6个月和12个月进行了测试，对另外124个病人在移植之后6个月、12个月进行了测试。83个仅在移植后12个月参加测试的病人没有被包括在这个分析中。这些病人中最常见的疾病是多发性骨髓瘤（63%）。

With the exception of attention, there was a significant improvement in cognitive abilities at 1 year. Performance on a battery of neuropsychologic tests that provided a total neuropsychologic performance score was at least as good as population normative values.
出乎研究人员意料的是，在移植后一年，患者的认知能力会有显著的提高。他们在一组神经心理学测试（这些测试会为一个人在神经心理学方面的表现提供一个分数）的表现至少达到了人群的平均值。

The researchers point out that although the group improved as a whole, "some patients may suffer from deficits for a longer period of time." Further research, they add, should concentrate on identifying such at-risk individuals.
研究人员指出，尽管总的来说患者的认知能力都有所提高，“但有些病人在此方面的缺陷可能存在更长一段时间。”他们补充说，进一步的研究将致力于确定那些高风险的人群。

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